منابع مشابه
Minding the store of Ca2+ during ischaemia/reperfusion.
Cardiac ischaemia puts a tremendous stress on cardiac myocytes, and abrupt reperfusion causes dramatic changes during the first seconds to minutes that profoundly affect cell survival vs. cell death. – 3 Myocyte ionic changes can contribute to these critical effects. During ischaemia, the concentration of intracellular Naþ ([Na]i) rises because of a combination of increased Naþ entry via Naþ/Hþ...
متن کاملExpansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store
Evidence accumulated over more than two decades has implicated Ca2+ dysregulation in brain aging and Alzheimer's disease (AD), giving rise to the Ca2+ hypothesis of brain aging and dementia. Electrophysiological, imaging, and behavioral studies in hippocampal or cortical neurons of rodents and rabbits have revealed aging-related increases in the slow afterhyperpolarization, Ca2+ spikes and curr...
متن کاملCanadian governance of health research involving human subjects: is anybody minding the store?
From an ethical perspective, good governance involves the translation of collective moral intentions into effective and accountable institutional actions. With respect to the use of human subjects in Canadian health research, I contend that there have been many good intentions but very little in the way of appropriate governance arrangements. Hence, the question, "who minds the store?" is espec...
متن کاملMinding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity.
Chronic low-level polychlorinated biphenyl (PCB) exposures remain a significant public health concern since results from epidemiological studies indicate that PCB burden is associated with immune system dysfunction, cardiovascular disease, and impairment of the developing nervous system. Of these various adverse health effects, developmental neurotoxicity has emerged as a particularly vulnerabl...
متن کاملMinding the gap.
T he ECWA Eye Hospital in Kano, Nigeria, is a mission hospital started by Dr Hursch, an American ophthalmologist, in the early 1940s. Although there are no surviving records from the time of Dr Hursch, I would venture to say that his practice of ophthalmology in Nigeria was not much different from his practice in America. Since the cutting edge tools of his day were loupes, and a small set of i...
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ژورنال
عنوان ژورنال: Mechanical Engineering
سال: 1999
ISSN: 0025-6501,1943-5649
DOI: 10.1115/1.1999-mar-5